PPIRE18699

Target Protein Information
Protein_Name Tumor necrosis factor ligand superfamily member 6
Protein_Sequence MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL
Organism_Source Homo sapiens
Functional_Classification tumor necrosis factor ligands
Cellular_Localization Extracellular
Gene_Names FASLG
UniProt_ID P48023
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 1
Peptide_Sequence LDTPVPRPPW
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification homoserine lactone
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1177.37
Aliphatic_Index 68.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 2.70000
Charge_at_pH_7 -0.00157
Isoelectric_Point 6.33872
Hydrogen_Bond_Acceptors 14
Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 425.28000
X_logP_energy -1.66883
Interaction Information
Affinity KD=400 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Rapid preparation of stable isotope labeled peptides that bind to target proteins by a phage library system
Release_Year 2006
PMID 16505961
DOI 10.1007/s10858-005-5054-0