PPIRE18700

Target Protein Information
Protein_Name Tumor necrosis factor ligand superfamily member 6
Protein_Sequence MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL
Organism_Source Homo sapiens
Functional_Classification tumor necrosis factor ligands
Cellular_Localization Extracellular
Gene_Names FASLG
UniProt_ID P48023
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 5
Peptide_Sequence SAQPFRLLTA
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification homoserine lactone
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1103.29
Aliphatic_Index 98.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.30000
Charge_at_pH_7 0.99798
Isoelectric_Point 10.55000
Hydrogen_Bond_Acceptors 15
Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 461.88000
X_logP_energy -4.45573
Interaction Information
Affinity KD=4000 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Rapid preparation of stable isotope labeled peptides that bind to target proteins by a phage library system
Release_Year 2006
PMID 16505961
DOI 10.1007/s10858-005-5054-0