PPIRE18712

Target Protein Information
Protein_Name Troponin C skeletal muscle
Protein_Sequence MASMTDQQAEARAFLSEEMIAEFKAAFDMFDADGGGDISTKELGTVMRMLGQNPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELANCFRIFDKNADGFIDIEELGEILRATGEHVTEEDIEDLMKDSDKNNDGRIDFDEFLKMMEGVQ
Organism_Source Gallus gallus
Functional_Classification calcium binding proteins
Cellular_Localization Cytoplasm
Gene_Names TNNC2
UniProt_ID P02588
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LII
Peptide_Sequence KSEEELANAFRIFEGEFDYIWEEDKVIIPIEEDLGELRATG
Peptide_Length 41
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(C)C)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4802.28
Aliphatic_Index 90.48780
Aromaticity 0.12195
Average_Rotatable_Bonds 3.97561
Charge_at_pH_7 -8.98437
Isoelectric_Point 3.76161
Hydrogen_Bond_Acceptors 63
Hydrogen_Bond_Donors 67
Topological_Polar_Surface_Area 1998.84000
X_logP_energy -13.21926
Interaction Information
Affinity KD=3 mM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Probing the Relationship between Alpha-Helix Formation and Calcium Affinity in Troponin C: 1H NMR Studies of Calcium Binding to Synthetic and Variant Site III Helix-Loop-Helix Peptides
Release_Year 1991
PMID 2001358
DOI 10.1021/bi00224a019