PPIRE18713

Target Protein Information
Protein_Name Ig gamma-2A chain C region A allele
Protein_Sequence AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK
Organism_Source Mus musculus
Functional_Classification immunoglobulin G
Cellular_Localization Extracellular
Gene_Names Ighg
UniProt_ID P01863
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CSSMGQWAKC
Peptide_Sequence CSSMGQWAKC
Peptide_Length 10
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; C1<-->C10; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1100.29
Aliphatic_Index 10.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 0.87374
Isoelectric_Point 8.22969
Hydrogen_Bond_Acceptors 18
Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 450.58000
X_logP_energy -5.87140
Interaction Information
Affinity IC50=56 nM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Analyte Peptidomimetics Selected from Phage Display Peptide Libraries: A Systematic Strategy for the Development of Environmental Immunoassays
Release_Year 2005
PMID 15984805
DOI 10.1021/es047931l