PPIRE18742
Target Protein Information
| Protein_Name | Tyrosine-protein kinase Lck |
|---|---|
| Protein_Sequence | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP |
| Organism_Source | Homo sapiens |
| Functional_Classification | tyrosine kinases |
| Cellular_Localization | Plasma membrane |
| Gene_Names | LCK |
| UniProt_ID | P06239 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ac-EpY(Aib)NH-NH2 |
|---|---|
| Peptide_Sequence | EYXNH |
| Peptide_Length | 5 |
| Peptide_SMILES | NC(=O)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O |
| Chemical_Modification | X3=2-aminoisobutyric acid; Y2=phosphorylation |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 618.60 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.20000 |
| Average_Rotatable_Bonds | 3.60000 |
| Charge_at_pH_7 | -0.91018 |
| Isoelectric_Point | 5.36345 |
|---|---|
| Hydrogen_Bond_Acceptors | 10 |
| Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 309.02000 |
| X_logP_energy | -3.37680 |
Interaction Information
| Affinity | IC50=0.49 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Dual Specificity of Src Homology 2 Domains for Phosphotyrosine Peptide Ligands |
| Release_Year | 1997 |
| PMID | 9153411 |
| DOI | 10.1021/bi962642y |