PPIRE18750
Target Protein Information
| Protein_Name | Growth factor receptor-bound protein 2 |
|---|---|
| Protein_Sequence | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV |
| Organism_Source | Homo sapiens |
| Functional_Classification | SH2 containing adaptor proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | GRB2 |
| UniProt_ID | P62993 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | H-VPEpYINQ-NH2 |
|---|---|
| Peptide_Sequence | HVPEYINQ |
| Peptide_Length | 8 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O |
| Chemical_Modification | Y5=phosphorylation |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 999.09 |
|---|---|
| Aliphatic_Index | 85.00000 |
| Aromaticity | 0.12500 |
| Average_Rotatable_Bonds | 3.62500 |
| Charge_at_pH_7 | -0.91018 |
| Isoelectric_Point | 5.36345 |
|---|---|
| Hydrogen_Bond_Acceptors | 14 |
| Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 430.62000 |
| X_logP_energy | -3.08000 |
Interaction Information
| Affinity | IC50=2.28 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Dual Specificity of Src Homology 2 Domains for Phosphotyrosine Peptide Ligands |
| Release_Year | 1997 |
| PMID | 9153411 |
| DOI | 10.1021/bi962642y |