PPIRE18785
Target Protein Information
| Protein_Name | Myelin basic protein |
|---|---|
| Protein_Sequence | ASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGSDRAAPKRGSGKDSHHAARTTHYGSLPQKSQRSQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQKPGFGYGGRADYKSKGFKGAHDAQGTLSKIFKLGGRDSRSGSPMARR |
| Organism_Source | Cavia porcellus |
| Functional_Classification | myelin basic proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | MBP |
| UniProt_ID | P25188 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | EAE CP |
|---|---|
| Peptide_Sequence | VFILGPLRLLG |
| Peptide_Length | 11 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1197.53 |
|---|---|
| Aliphatic_Index | 203.63636 |
| Aromaticity | 0.09091 |
| Average_Rotatable_Bonds | 3.36364 |
| Charge_at_pH_7 | 0.99798 |
| Isoelectric_Point | 10.55000 |
|---|---|
| Hydrogen_Bond_Acceptors | 13 |
| Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 407.43000 |
| X_logP_energy | 0.40777 |
Interaction Information
| Affinity | KD=4 pM |
|---|---|
| Affinity_Assay | solid-phase binding assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Studies on T-cell receptors involved in experimental autoimmune encephalomyelitis using the complementary peptide recognition approach |
| Release_Year | 1995 |
| PMID | 7563242 |
| DOI | 10.1002/jnr.490410508 |