PPIRE18803

Target Protein Information
Protein_Name Ig gamma-2A chain C region A allele
Protein_Sequence AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK
Organism_Source Mus musculus
Functional_Classification antibodies
Cellular_Localization Extracellular
Gene_Names Ighg
UniProt_ID P01863
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PAK pilin peptide (PAK128-144)
Peptide_Sequence KCTSDQDEQFIPKGCSKX
Peptide_Length 18
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O
Chemical_Modification X18=homoserine
Cyclization_Method Side chain-side chain cyclization; C2<-->C15; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1971.19
Aliphatic_Index 21.66667
Aromaticity 0.05556
Average_Rotatable_Bonds 3.77778
Charge_at_pH_7 -0.12418
Isoelectric_Point 6.28153
Hydrogen_Bond_Acceptors 32
Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 886.06000
X_logP_energy -12.34510
Interaction Information
Affinity KD=0.16 uM
Affinity_Assay ELISA
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Interaction of a Peptide from the Receptor-Binding Domain of Pseudomonas aeruginosa Pili Strain PAK with a Cross-Reactive Antibody: Changes in Backbone Dynamics Induced by Binding
Release_Year 2003
PMID 14503884
DOI 10.1021/bi030102c