PPIRE18814

Target Protein Information
Protein_Name Tyrosine-protein kinase Lck
Protein_Sequence MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
Organism_Source Homo sapiens
Functional_Classification tyrosine kinases
Cellular_Localization Cytoplasm
Gene_Names LCK
UniProt_ID P06239
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CD4
Peptide_Sequence EKKTCQCPHRFQKY
Peptide_Length 14
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1796.10
Aliphatic_Index 0.00000
Aromaticity 0.14286
Average_Rotatable_Bonds 4.28571
Charge_at_pH_7 2.96498
Isoelectric_Point 9.46123
Hydrogen_Bond_Acceptors 27
Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 765.41000
X_logP_energy -7.34983
Interaction Information
Affinity KD=90.91 uM
Affinity_Assay UV/visible absorption spectroscopy with cobalt(II)
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Homodimerization and Heterodimerization of Minimal Zinc(II)-Binding-Domain Peptides of T-Cell Proteins CD4 CD8r and Lck
Release_Year 2009
PMID 19624124
DOI 10.1021/ja9028928