PPIRE18815

Target Protein Information
Protein_Name Tyrosine-protein kinase Lck
Protein_Sequence MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
Organism_Source Homo sapiens
Functional_Classification tyrosine kinases
Cellular_Localization Cytoplasm
Gene_Names LCK
UniProt_ID P06239
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CD8R
Peptide_Sequence RRRVCKCPRPVVKSY
Peptide_Length 15
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1847.28
Aliphatic_Index 58.00000
Aromaticity 0.06667
Average_Rotatable_Bonds 3.93333
Charge_at_pH_7 5.87258
Isoelectric_Point 11.50709
Hydrogen_Bond_Acceptors 26
Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 793.24000
X_logP_energy -7.72282
Interaction Information
Affinity KD=45.45 uM
Affinity_Assay UV/visible absorption spectroscopy with cobalt(II)
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Homodimerization and Heterodimerization of Minimal Zinc(II)-Binding-Domain Peptides of T-Cell Proteins CD4 CD8r and Lck
Release_Year 2009
PMID 19624124
DOI 10.1021/ja9028928