PPIRE18816

Target Protein Information
Protein_Name Tyrosine-protein kinase Lck
Protein_Sequence MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
Organism_Source Homo sapiens
Functional_Classification tyrosine kinases
Cellular_Localization Cytoplasm
Gene_Names LCK
UniProt_ID P06239
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Lck(CEC)
Peptide_Sequence ENIDVCECHYPIVPL
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C)[C@@H](C)CC)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1744.01
Aliphatic_Index 116.66667
Aromaticity 0.06667
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 -3.03191
Isoelectric_Point 3.92631
Hydrogen_Bond_Acceptors 24
Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 657.04000
X_logP_energy -3.49840
Interaction Information
Affinity KD=3.57 uM
Affinity_Assay UV/visible absorption spectroscopy with cobalt(II)
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Homodimerization and Heterodimerization of Minimal Zinc(II)-Binding-Domain Peptides of T-Cell Proteins CD4 CD8r and Lck
Release_Year 2009
PMID 19624124
DOI 10.1021/ja9028928