PPIRE18836
Target Protein Information
| Protein_Name | Protein E6 |
|---|---|
| Protein_Sequence | MDLKPFARTNPFSGLDCLWCREPLTEVDAFRCMVKDFHVVIREGCRYGACTICLENCLATERRLWQGVPVTGEEAELLHGKTLDRLCIRCCYCGGKLTKNEKHRHVLFNEPFCKTRANIIRGRCYDCCRHGSRSKYP |
| Organism_Source | Bovine papillomavirus type 1 |
| Functional_Classification | viral oncoproteins |
| Cellular_Localization | Nucleus |
| Gene_Names | E6 |
| UniProt_ID | P06931 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | E6AP LXXLL peptide |
|---|---|
| Peptide_Sequence | ESSELTLQELLGEER |
| Peptide_Length | 15 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1732.86 |
|---|---|
| Aliphatic_Index | 104.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.13333 |
| Charge_at_pH_7 | -3.99314 |
| Isoelectric_Point | 3.70649 |
|---|---|
| Hydrogen_Bond_Acceptors | 26 |
| Hydrogen_Bond_Donors | 28 |
| Topological_Polar_Surface_Area | 822.90000 |
| X_logP_energy | -8.78053 |
Interaction Information
| Affinity | KD=1.3 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Strategies for bacterial expression of protein-鍌欒兌閸嬨劑宕曢弻銉ョ畺闁哄嫮鎯ide complexes: Application to solubilization of papillomavirus E6 |
| Release_Year | 2011 |
| PMID | 21777678 |
| DOI | 10.1016/j.pep.2011.06.013 |