PPIRE18845

Target Protein Information
Protein_Name Glycophorin-A
Protein_Sequence MYGKIIFVLLLSEIVSISALSTTEVAMHTSTSSSVTKSYISSQTNDTHKRDTYAATPRAHEVSEISVRTVYPPEEETGERVQLAHHFSEPEITLIIFGVMAGVIGTILLISYGIRRLIKKSPSDVKPLPSPDTDVPLSSVEIENPETSDQ
Organism_Source Homo sapiens
Functional_Classification glycoproteins
Cellular_Localization Plasma membrane
Gene_Names GYPA
UniProt_ID P02724
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide 1779
Peptide_Sequence NIDRIYDKNLLMIKEHILAI
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2425.91
Aliphatic_Index 161.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 4.25000
Charge_at_pH_7 0.09012
Isoelectric_Point 7.54151
Hydrogen_Bond_Acceptors 32
Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 977.15000
X_logP_energy -4.24833
Interaction Information
Affinity KD=175 nM
Affinity_Assay receptor-ligand assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Immunogenicity and protectivity of Plasmodium falciparum EBA-175 peptide and its analog is associated with alpha-helical region shortening and displacement
Release_Year 2003
PMID 14669987
DOI 10.1515/BC.2003.160