PPIRE18847
Target Protein Information
| Protein_Name | Triggering receptor expressed on myeloid cells 1 |
|---|---|
| Protein_Sequence | MRKAGLWGLLCVFFVSEVKAAIVLEEERYDLVEGQTLTVKCPFNIMKYANSQKAWQRLPDGKEPLTLVVTQRPFTRPSEVHMGKFTLKHDPSEAMLQVQMTDLQVTDSGLYRCVIYHPPNDPVVLFHPVRLVVTKGSSDVFTPVIIPITRLTERPILITTKYSPSDTTTTRSLPKPTAVVSSPGLGVTIINGTDADSVSTSSVTISVICGLLSKSLVFIILFIVTKRTFG |
| Organism_Source | Mus musculus |
| Functional_Classification | immunoglobulin superfamily |
| Cellular_Localization | Plasma membrane |
| Gene_Names | Trem1 |
| UniProt_ID | Q9JKE2 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | M3 |
|---|---|
| Peptide_Sequence | RGFFRGG |
| Peptide_Length | 7 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 795.90 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.28571 |
| Average_Rotatable_Bonds | 3.57143 |
| Charge_at_pH_7 | 1.99798 |
| Isoelectric_Point | 12.50011 |
|---|---|
| Hydrogen_Bond_Acceptors | 10 |
| Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 361.72000 |
| X_logP_energy | -3.78676 |
Interaction Information
| Affinity | KD=118 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | An extracellular cold-inducible RNA-binding protein-derived small peptide targeting triggering receptor expressed on myeloid cells-1 attenuates hemorrhagic shock |
| Release_Year | 2020 |
| PMID | 32453257 |
| DOI | 10.1097/TA.0000000000002664 |