PPIRE18848

Target Protein Information
Protein_Name Glycophorin-A
Protein_Sequence MYGKIIFVLLLSEIVSISALSTTEVAMHTSTSSSVTKSYISSQTNDTHKRDTYAATPRAHEVSEISVRTVYPPEEETGERVQLAHHFSEPEITLIIFGVMAGVIGTILLISYGIRRLIKKSPSDVKPLPSPDTDVPLSSVEIENPETSDQ
Organism_Source Homo sapiens
Functional_Classification sialoglycoproteins
Cellular_Localization Plasma membrane
Gene_Names GYPA
UniProt_ID P02724
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 1818
Peptide_Sequence NNNFNNIPSRYNLYDKKLDL
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2455.71
Aliphatic_Index 78.00000
Aromaticity 0.15000
Average_Rotatable_Bonds 4.05000
Charge_at_pH_7 0.99658
Isoelectric_Point 9.12116
Hydrogen_Bond_Acceptors 35
Hydrogen_Bond_Donors 36
Topological_Polar_Surface_Area 1115.20000
X_logP_energy -11.84523
Interaction Information
Affinity KD=146 nM
Affinity_Assay erythrocyte binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Orientating Peptide Residues and Increasing the Distance between Pockets to Enable Fitting into MHC-TCR Complex Determine Protection against Malaria
Release_Year 2004
PMID 15157087
DOI 10.1021/bi049698+