PPIRE18861
Target Protein Information
| Protein_Name | Neuropeptide Y receptor type 2 |
|---|---|
| Protein_Sequence | MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV |
| Organism_Source | Homo sapiens |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | NPY2R |
| UniProt_ID | P49146 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | 5b |
|---|---|
| Peptide_Sequence | LPPYY |
| Peptide_Length | 5 |
| Peptide_SMILES | CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 651.76 |
|---|---|
| Aliphatic_Index | 78.00000 |
| Aromaticity | 0.40000 |
| Average_Rotatable_Bonds | 2.60000 |
| Charge_at_pH_7 | -0.00372 |
| Isoelectric_Point | 6.08660 |
|---|---|
| Hydrogen_Bond_Acceptors | 8 |
| Hydrogen_Bond_Donors | 6 |
| Topological_Polar_Surface_Area | 202.60000 |
| X_logP_energy | 1.29260 |
Interaction Information
| Affinity | IC50=0.23 nM |
|---|---|
| Affinity_Assay | Radioligand binding assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | On the terminal homologation of physiologically active peptides as a means of increasing stability in human serum--neurotensin opiorphin B27-KK10 epitope NPY |
| Release_Year | 2011 |
| PMID | 21560227 |
| DOI | 10.1002/cbdv.201100093 |