PPIRE18875

Target Protein Information
Protein_Name None
Protein_Sequence MKMKIPICFLIILVLLKCVLSYNLNNDLSKNNNFSLNTYVRKDDVEDDSKNEIVDNIQKMVDDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQNISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYETEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDLNMALS
Organism_Source Plasmodium falciparum (isolate 3D7)
Functional_Classification microneme proteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID Q8IDR4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HABP 33372
Peptide_Sequence ASLEEVSDHVVQNISKYSLT
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)N)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2219.43
Aliphatic_Index 107.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.70000
Charge_at_pH_7 -1.90826
Isoelectric_Point 4.42146
Hydrogen_Bond_Acceptors 34
Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 990.38000
X_logP_energy -11.52600
Interaction Information
Affinity KD=850 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Biological and structural characteristics of the binding peptides from the sporozoite proteins essential for cell traversal (SPECT)-1 and -2
Release_Year 2011
PMID 20933029
DOI 10.1016/j.peptides.2010.09.026