PPIRE18876

Target Protein Information
Protein_Name None
Protein_Sequence MKMKIPICFLIILVLLKCVLSYNLNNDLSKNNNFSLNTYVRKDDVEDDSKNEIVDNIQKMVDDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQNISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYETEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDLNMALS
Organism_Source Plasmodium falciparum (isolate 3D7)
Functional_Classification microneme proteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID Q8IDR4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HABP 33374
Peptide_Sequence LISNLSKRQQKLKGDKIKKVY
Peptide_Length 21
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2488.02
Aliphatic_Index 106.66667
Aromaticity 0.04762
Average_Rotatable_Bonds 4.47619
Charge_at_pH_7 5.99581
Isoelectric_Point 11.11769
Hydrogen_Bond_Acceptors 36
Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1090.60000
X_logP_energy -9.53653
Interaction Information
Affinity KD=750 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Biological and structural characteristics of the binding peptides from the sporozoite proteins essential for cell traversal (SPECT)-1 and -2
Release_Year 2011
PMID 20933029
DOI 10.1016/j.peptides.2010.09.026