PPIRE18877

Target Protein Information
Protein_Name None
Protein_Sequence MKMKIPICFLIILVLLKCVLSYNLNNDLSKNNNFSLNTYVRKDDVEDDSKNEIVDNIQKMVDDFSDDIGFVKTSMREVLLDTEASLEEVSDHVVQNISKYSLTIEEKLNLFDGLLEEFIENNKGLISNLSKRQQKLKGDKIKKVCDLILKKLKKLENVNKLIKYKIILKYGNKDNKKEMIQTLKNEEGLSDDFKNNLSNYETEQNNDDIKEIELVNFISTNYDKFVVNLEDLNKELLKDLNMALS
Organism_Source Plasmodium falciparum (isolate 3D7)
Functional_Classification microneme proteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID Q8IDR4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HABP 33375
Peptide_Sequence TDLILKKLKKLENVNKLIKY
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2415.00
Aliphatic_Index 151.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 4.50000
Charge_at_pH_7 3.99759
Isoelectric_Point 10.58085
Hydrogen_Bond_Acceptors 33
Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 973.58000
X_logP_energy -4.21840
Interaction Information
Affinity KD=750 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Biological and structural characteristics of the binding peptides from the sporozoite proteins essential for cell traversal (SPECT)-1 and -2
Release_Year 2011
PMID 20933029
DOI 10.1016/j.peptides.2010.09.026