PPIRE18878

Target Protein Information
Protein_Name None
Protein_Sequence MKLRILKKHYYVVFILLYLYDISCFKCIRLNNRSIYKNKYKNNVHIGTNENIRSIEKYSNVLCNSILCKNDKISSFINQRKNVDDDDESENDDMYESTTAGSSSETDNESDEEENDSSDNNNSDEEQIENSNNNNSDEEQNDSSSNDNNDEENEEQDDVMDNDQNDKKIKHSFNLANESKHTKEERVKEEKKLKIYDFINDKEKRLNFNGDQKDEDNEENDDKDENTLENRNIISKHTSVFPGLYFIGIGYNLLFGNPLGEADSLIDPGYRAQIYLMEWALSKEGIANDLSTLQPVNGWIRKENACSRVESITECSSISDYTKSLSAEAKVSGSYWGIASFSASTGYSSFLHEVTKRSKKTFLVKSNCVKYTIGLPPYIPWDKTTAYKNAVNELPAVFTGLDKESECPSDVYEENKTKSNCENVSLWMKFFDIYGTHIIYESQLGGKITKIINVSTSSIEQMKKNGVSVKAKIQAQFGFGSAGGSTDVNSSNSSANDEQSYDMNEQLIVIGGNPIKDVTKEENLFEWSKTVTNHPMPINIKLTPISDSFDSDDLKESYDKAIIYYSRLYGLSPHDTMQKDDKDIIKILTNADTVTKNSAPPINAQCPHGKVVMFGFSLKQNFWDNTNALKGYNIEVCEAGSNSCTSKQGSSNKYDTSYLYMECGDQPLPFSEQVISESTSTYNTVKCPNDYSILLGFGISSSSGRINSAEYVYSTPCIPGMKSCSLNMNNDNQKSYIYVLCVDTTIWSGVNNLSLVALDGAHGKVNRSKKYSDGELVGTCPLDGTVLTGFKVEFHTSSPYVQTPFEKCAKSLKACSVHGSGHAIGIQNFKSLFIYMLCKNNK
Organism_Source Plasmodium falciparum (isolate 3D7)
Functional_Classification microneme proteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID Q9U0J9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HABP 34925
Peptide_Sequence VLCNSILCKNDKISSFINQRY
Peptide_Length 21
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2458.88
Aliphatic_Index 106.66667
Aromaticity 0.09524
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 1.87304
Isoelectric_Point 8.79238
Hydrogen_Bond_Acceptors 36
Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1049.84000
X_logP_energy -11.10403
Interaction Information
Affinity KD=680 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Biological and structural characteristics of the binding peptides from the sporozoite proteins essential for cell traversal (SPECT)-1 and -2
Release_Year 2011
PMID 20933029
DOI 10.1016/j.peptides.2010.09.026