PPIRE18908
Target Protein Information
| Protein_Name | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
|---|---|
| Protein_Sequence | MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ |
| Organism_Source | Homo sapiens |
| Functional_Classification | protein prenyltransferases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | FNTA |
| UniProt_ID | P49354 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | CVVM |
|---|---|
| Peptide_Sequence | CVVM |
| Peptide_Length | 4 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 450.61 |
|---|---|
| Aliphatic_Index | 145.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.25000 |
| Charge_at_pH_7 | -0.06399 |
| Isoelectric_Point | 5.92254 |
|---|---|
| Hydrogen_Bond_Acceptors | 7 |
| Hydrogen_Bond_Donors | 6 |
| Topological_Polar_Surface_Area | 150.62000 |
| X_logP_energy | -0.15240 |
Interaction Information
| Affinity | IC50=3 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | High-performance liquid chromatographic assay for farnesyl-protein transferase activity with dabsylated peptide |
| Release_Year | 1995 |
| PMID | 7794931 |
| DOI | 10.1021/bi00025a024 |