PPIRE18919
Target Protein Information
| Protein_Name | Envelope glycoprotein gp150 |
|---|---|
| Protein_Sequence | MAEGFAANRQWIGPEEAEELLDFDIATQMSEEGPLNPGVNPFRVPGITEKEKQNYCNILQPKLQDLRNEIQEVKLEEGNAGKFRRARFLRYSDERVLSLVHAFIGYCIYLGNRNKLGSLRHDIDIEAPQEECYNNREKGTTDNIKYGRRCCLGTVTLYLILFTGVIVYSQTAGAQVVWRLPPLVVPVEESEIIFWDCWAPEEPACQDFLGAMIHLKAKTNISIREGPTLGNWAREIWATLFKKATRQCRRGRIWKRWNETITGPSGCANNTCYNVSVIVPDYQCYLDRVDTWLQGKINISLCLTGGKMLYNKVTKQLSYCTDPLQIPLINYTFGPNQTCMWNTSQIQDPEIPKCGWWNQMAYYNSCKWEEAKVKFHCQRTQSQPGSWFRAISSWKQRNRWEWRPDFKSKKVKISLPCNSTKNLTFAMRSSGDYGEVTGAWIEFGCHRNKSNLHTEARFRIRCRWNVGSDTSLIDTCGNTPNVSGANPVDCTMYSNKMYNCSLQNGFTMKVDDLIVHFNMTKAVEMYNIAGNWSCTSDLPSSWGYMNCNCTNSSSSYSGTKMACPSNRGILRNWYNPVAGLRQSLEQYQVVKQPDYLLVPEEVMEYKPRRKRAAIHVMLALATVLSIAGAGTGATAIGMVTQYHQVLATHQEAIEKVTGALKINNLRLVTLEHQVLVIGLKVEAMEKFLYTAFAMQELGCNQNQFFCKIPLELWTRYNMTINQTIWNHGNITLGEWYNQTKDLQQKFYEIIMDIEQNNVQGKTGIQQLQKWEDWVRWIGNIPQYLKGLLGGILGIGLGVLLLILCLPTLVDCIRNCIHKILGYTVIAMPEVEGEEIQPQMELRRNGRQCGMSEKEEE |
| Organism_Source | Feline immunodeficiency virus (isolate Petaluma) |
| Functional_Classification | envelope glycoproteins |
| Cellular_Localization | Extracellular |
| Gene_Names | env |
| UniProt_ID | P16090 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | C8 |
|---|---|
| Peptide_Sequence | WEDWVGWI |
| Peptide_Length | 8 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1090.20 |
|---|---|
| Aliphatic_Index | 85.00000 |
| Aromaticity | 0.37500 |
| Average_Rotatable_Bonds | 3.62500 |
| Charge_at_pH_7 | -1.99979 |
| Isoelectric_Point | 3.55007 |
|---|---|
| Hydrogen_Bond_Acceptors | 11 |
| Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 388.99000 |
| X_logP_energy | 1.63690 |
Interaction Information
| Affinity | KD=1.2 uM |
|---|---|
| Affinity_Assay | fluorescence spectroscopy |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural features of the C8 antiviral peptide in a membrane-mimicking environment |
| Release_Year | 2014 |
| PMID | 24369115 |
| DOI | 10.1016/j.bbamem.2013.12.010 |