PPIRE18992

Target Protein Information
Protein_Name Growth factor receptor-bound protein 2
Protein_Sequence MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Organism_Source Homo sapiens
Functional_Classification Adaptor scaffold proteins
Cellular_Localization Cytoplasm
Gene_Names GRB2
UniProt_ID P62993
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Sos proline-rich decapeptide VPPPVPPRRR
Peptide_Sequence VPPPVPPRRR
Peptide_Length 10
Peptide_SMILES CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1170.43
Aliphatic_Index 58.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.80000
Charge_at_pH_7 2.99797
Isoelectric_Point 12.80107
Hydrogen_Bond_Acceptors 14
Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 466.97000
X_logP_energy -3.60569
Interaction Information
Affinity KD=4.6 uM
Affinity_Assay circular dichroism
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Circular Dichroic Investigation of the Native and Non-native Conformational States of the Growth Factor Receptor-Binding Protein 2 N-Terminal src Homology Domain 3: Effect of Binding to a Proline-rich Peptide from Guanine Nucleotide Exchange Factor
Release_Year 2000
PMID 10869177
DOI 10.1021/bi9929103