PPIRE19000
Target Protein Information
| Protein_Name | Insulin |
|---|---|
| Protein_Sequence | MALWTRLRPLLALLALWPPPPARAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEGPQVGALELAGGPGAGGLEGPPQKRGIVEQCCASVCSLYQLENYCN |
| Organism_Source | Bos taurus |
| Functional_Classification | peptide hormone |
| Cellular_Localization | Extracellular |
| Gene_Names | INS |
| UniProt_ID | P01317 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | KR7CC |
|---|---|
| Peptide_Sequence | KCPWWPCRR |
| Peptide_Length | 9 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C2<-->C7; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1231.50 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.22222 |
| Average_Rotatable_Bonds | 3.66667 |
| Charge_at_pH_7 | 2.87373 |
| Isoelectric_Point | 9.91456 |
|---|---|
| Hydrogen_Bond_Acceptors | 15 |
| Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 459.94000 |
| X_logP_energy | -1.74776 |
Interaction Information
| Affinity | KD=3.5 uM |
|---|---|
| Affinity_Assay | fluorescence anisotropy |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Targeted inhibition of amyloidogenesis using a non-toxic serum stable strategically designed cyclic peptide with therapeutic implications |
| Release_Year | 2020 |
| PMID | 32032759 |
| DOI | 10.1016/j.bbapap.2020.140378 |