PPIRE19011

Target Protein Information
Protein_Name Proteasome subunit beta type-5
Protein_Sequence MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
Organism_Source Homo sapiens
Functional_Classification proteasome
Cellular_Localization Cytoplasm
Gene_Names PSMB5
UniProt_ID P28074
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name roseltide rT7
Peptide_Sequence CVSSGIVDACSECCEPDKCIIMLPTWPPRYVCSV
Peptide_Length 34
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3705.38
Aliphatic_Index 82.94118
Aromaticity 0.05882
Average_Rotatable_Bonds 3.26471
Charge_at_pH_7 -2.37057
Isoelectric_Point 4.10515
Hydrogen_Bond_Acceptors 54
Hydrogen_Bond_Donors 52
Topological_Polar_Surface_Area 1362.75000
X_logP_energy -12.69333
Interaction Information
Affinity IC50=3.3 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Disulfide-rich proteasome inhibitor Roseltide rT7 is a disulfide-rich anionic and cell-penetrating peptide that inhibits proteasomal degradation
Release_Year 2019
PMID 31727740
DOI 10.1074/jbc.RA119.010796