PPIRE19029
Target Protein Information
| Protein_Name | Apolipoprotein N-acyltransferase |
|---|---|
| Protein_Sequence | MLGLYARGGLAWGLGFVALVPWLLALGRGTTLHGALASGALMSVAFVAAVFYWFGAAIGAYVGVGATTATAALLALAPLMQPQWLAFALARQWAGRRYGPALRALAATSAWLACEWLAPKALGDTLGHGLYPSATLRQVADLGGAAGLTALLLLVNEAVATAIERRGQGARALARPLAAAALIVACMAGYGMARRAALQAPPAPAQSLRVAMVQASIVDYERLRGQIGAYAVVRKVLDAHYALSASAINDHGADVLLWSETVYPTSFGHPRSEDGAAFDRELQGFVDHAGVPLVFGTYDRDALGEYNAAALLEPGKGLLGVYRKTYPFPLTEYVPAWLDGPLLRRALPWTGGWRPGDGARVLPLRSADGREVNVVPLICLDDVHPDLAIDGARLGAQAIVGMSNDSWFTHYPVGARLHLAVAAFRSIETRLPQVRVTSNGLSAIIDESGEVLAHTATGDRAVLTAAIGARAPMPTLMVRWGDWVGRAGAGVLLGLALLAVWQSARRRAAAAAREETTVDAVVLTPPWRALAGALRLCAGLGLAWLAFDMLTRIGLQIQSLSQLRLFAMAVVAPAVAAWAIGRAFAAQLRVEDGMWVLEQRRQRIELPLASVAALRPWRIALPGSGVDVRLAEGPRWTRGLALARPQSLLRLLAAGGASVRWEGRFAAAWAEWVQARADAHRRRLDHPLAKFALLPLLLALVAFRLHQVIAFGGTFGEYYSYGLGAYLTGLLIWWASWSIGLMLLAAVLRIGIEAAVAAAAILRATQAAAVRDALEWLGRAAFYLGVPAWLAWRLLSAG |
| Organism_Source | Lysobacter enzymogenes |
| Functional_Classification | serine proteases |
| Cellular_Localization | Extracellular |
| Gene_Names | lnt |
| UniProt_ID | A0A0S2DJ72 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | N-tert-butyloxycarbonyl-Ala-Pro-boroVal |
|---|---|
| Peptide_Sequence | APX |
| Peptide_Length | 3 |
| Peptide_SMILES | C[C@H](N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O |
| Chemical_Modification | X3=boroVal |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | tert-butyloxycarbonyl |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 243.26 |
|---|---|
| Aliphatic_Index | 33.33333 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 1.33333 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Hydrogen_Bond_Acceptors | 4 |
| Hydrogen_Bond_Donors | 3 |
| Topological_Polar_Surface_Area | 112.73000 |
| X_logP_energy | -1.47460 |
Interaction Information
| Affinity | Ki=0.35 nM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | 1P01 |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to alpha-lytic protease |
| Release_Year | 1997 |
| PMID | 9335113 |
| DOI | 10.1023/a:1018314808361 |