PPIRE19031

Target Protein Information
Protein_Name Lysozyme C
Protein_Sequence MRSLLILVLCFLPLAALGKVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL
Organism_Source Gallus gallus
Functional_Classification glycosidases
Cellular_Localization Extracellular
Gene_Names LYZ
UniProt_ID P00698
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Cys6-7
Peptide_Sequence VNIACNPTDIQCLIRLPAEXXK
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O
Chemical_Modification X20=biotinylated lysine; X21=norleucine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2325.73
Aliphatic_Index 110.90909
Aromaticity 0.00000
Average_Rotatable_Bonds 3.40909
Charge_at_pH_7 -0.12404
Isoelectric_Point 6.22098
Hydrogen_Bond_Acceptors 33
Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 968.86000
X_logP_energy -10.23093
Interaction Information
Affinity KD=64.5 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The Role of Structure in Antibody Cross-reactivity Between Peptides and Folded Proteins
Release_Year 1998
PMID 9680484
DOI 10.1006/jmbi.1998.1907