PPIRE19069

Target Protein Information
Protein_Name None
Protein_Sequence WDCKKKNDRSNYVCIPDRRIQLCIVNLSIIKTYTKETMKDHFIEASKKESQLLLKKNDNKYNSKFCNDLKNSFLDYGHLAMGNDMDFGGYSTKAENKIQEVFKGAHGEISEHEIKNFRKKWWNEFREKLWEAMLSEHKNNINNCKNIPQEELQITQWIKEWHGEFLLERDNRSKLPKSKCKNNTLYEACEKECIDPCMKYRDWIIRSKFEWHTLSKEYETQKVSKENAENYLIKISENKNDAKV
Organism_Source Plasmodium falciparum
Functional_Classification erythrocyte binding proteins
Cellular_Localization Extracellular
Gene_Names EBA175
UniProt_ID A0A159SL51
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pep1815
Peptide_Sequence YTNQNINISQERDLQKHGFH
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2442.63
Aliphatic_Index 58.50000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.15000
Charge_at_pH_7 0.18088
Isoelectric_Point 7.70523
Hydrogen_Bond_Acceptors 36
Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1155.33000
X_logP_energy -13.97063
Interaction Information
Affinity KD=106 nM
Affinity_Assay erythrocyte binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit into HLA-DR1*03 molecules induces antibody production and protection
Release_Year 2005
PMID 15694510
DOI 10.1016/j.vaccine.2004.08.052