PPIRE19119
Target Protein Information
| Protein_Name | Genome polyprotein |
|---|---|
| Protein_Sequence | TTQGCNCSIYPGHITGHRMAWDMMMNWSPTTALVVAQLLRIPQAILDMIAGAHWGVLAGIAYFSMVGNWAKVLAVLLLFAGVDAETHVTGGIAAKTTASLTGLFNLGAKQNIQLINTNGSWHINRTALNCNDSLNTGW |
| Organism_Source | Hepatitis C virus (isolate EC10) |
| Functional_Classification | glycoproteins |
| Cellular_Localization | Extracellular |
| Gene_Names | None |
| UniProt_ID | P27953 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Peptide 1 |
|---|---|
| Peptide_Sequence | PSGSNIISNLFKED |
| Peptide_Length | 14 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)CC |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1520.66 |
|---|---|
| Aliphatic_Index | 83.57143 |
| Aromaticity | 0.07143 |
| Average_Rotatable_Bonds | 3.64286 |
| Charge_at_pH_7 | -1.00009 |
| Isoelectric_Point | 4.18441 |
|---|---|
| Hydrogen_Bond_Acceptors | 23 |
| Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 675.12000 |
| X_logP_energy | -8.66600 |
Interaction Information
| Affinity | IC50=3.5 mM |
|---|---|
| Affinity_Assay | flow cytometry |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural characterization of peptide fragments from hCD81-LEL |
| Release_Year | 2003 |
| PMID | 12492902 |
| DOI | 10.1034/j.1399-3011.2003.00038.x |