PPIRE19121

Target Protein Information
Protein_Name Growth factor receptor-bound protein 2
Protein_Sequence MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYVTPYHS
Organism_Source Drosophila melanogaster
Functional_Classification SH3 domain
Cellular_Localization Cytoplasm
Gene_Names drk
UniProt_ID Q08012
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PepS2
Peptide_Sequence YRAVPPPLPPRR
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1418.71
Aliphatic_Index 65.00000
Aromaticity 0.08333
Average_Rotatable_Bonds 2.91667
Charge_at_pH_7 2.99712
Isoelectric_Point 12.20421
Hydrogen_Bond_Acceptors 17
Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 545.40000
X_logP_energy -3.27779
Interaction Information
Affinity KD=230 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Protein-Peptide Binding Energetics under Crowded Conditions
Release_Year 2020
PMID 32936642
DOI 10.1021/acs.jpcb.0c05578