PPIRE19139

Target Protein Information
Protein_Name None
Protein_Sequence MAPQKAAAPDYSSAKDAKELLDMIGEEVYKEKVKNAANDFREKLKGTLSQATFEEAPKEQQTPGNPCELKYQWHTNATRGKNYPCRTGTEKRFSEVSGGECDEKKIKDNKGKEGACAPYRRLHLCVRNLENISALDKINNDTLLADVCLAALHEGAAISADHGQYQQTNDSSQLCTMLARSFADIGDIIRGKDLYRGNNGKDKLEENLKKIFGNIYKDVTKGGKNVDALKTRYEDATGNYYKLREDWWNANRQEIWKALTCDAPNGDVHYFRKTCSMGQSHVNDKCRCLNGDPPTYFDYVPQYLRWFEEWAEDFCTKRKHKLQNAIKICRGDSGNDRYCDLNGYDCTKTARGKNKRFSNDECYKCSLPCDHFVPWIDNQQKEFEKQKKKYAEEIKKAEEKKETSITIGDKTINNLYVQEFYQQLQSSYKDVEDFLQKLNEERICKKPPTVGKETADPVDFTKGKTEKTFSRTEYCRACPWCGIKRKADGTWERLDDMNKCVKEKKTYEKKNITDIPVLTPDKSQSRILDKYKNFCDDTNGKNSNGQKEKWECYYKKNEKDDVNGDSNICVLQNDKQNTEEENDRSYNSFFWKWVTEMLIDSIDWRKELKRCTNNKRGKCKNKKCNNDCKCFERWIEEKKNEWEKIVDYFKTQPGFDILSNNYDLALKTLLDVEDILTNIEDGYKEVKGSEHIRKMLENEKNQEEAAVAVTVKRNTIDLLIEHELDEADLCLDTHLEDEDCSDEDDDHEEEVYVNNPCAKPSGSYPSLANEAAHQMHKAAKTQLSGRGGRRTLKADASKGEYKRGGQGNTLNGDICKITKNYTNDIRSNGGACKGKDGSNERFKIGTEWSNVEDKKTTSYSDVYLPPRREHMCTSNLENLDVGSVTENGKAIHSLLGDVILTAKMDAAEIINRYKSQNSIGDPIDKKHQESICRAIRYSFADIGDIIRGRDIWDNETGMNHLKGHLEKVFKNIKEKLPGIQDKYTGDEKNNPPYKLLREDWWEANRHQVWRAMKCATKKDKNMKCNGIPIEDYIPQRLRWMTEWSEWFCKMQSVEYEKLKEKCDNCKNKDGGKDCTNVDSVCKPCAKQCKEYKEKIKNWEEQWRKISDKYNLLYLQAETTARNAGATSFDGTDPDYKQVVDFFKELQKTIKSSASKRPKRSTDGTTTDPTLTSPYFTAAGYIHQELPNMGCISQTHFCGDNNKKEYAFRDKPTDHDKVCDCESGEKLQYKKKEGIVLEEPCNVVKTLLKDKNENSDIGECIRKYKDGNEKYPVWDCTRNKIKIGEEGAYMPPRRQKLCVDFLKQLKDQTDEKLRDAFIKSAAAETFLSWHKYKEDKKKENPTEEAPSLDVEAQTQLNDGIIPEEFKRQMFYTFGDYRDLCLGKDIGNDVPIVNNNITTAFQNGAQNPSDQDTDSQRQVFWGTYGKDIWEGMLCALEKITEKQMTFTDKHEYTFDKVTFSGDKSPILEKFAQTPQFLRWMTEWGEHFCRERKEKVEILRTECAGCEVSDNDGSCHKNGEECQKCREECKKYQKWLEKWRENYDKQKVKFKTDKEGYNDDPDTIQSTEAYEYLGKKLKNITFTSGTTNGDCKCMQEKSKQESHDGSITDNMPESLDKEPQEVRGKCTCDSPTKKPEVLPVSPTSQDEACKIVDAILDPNSGTGYNDACEEKYGNGKTAYPGWKCTTNKIEKGKEDDVVCIPPRRQKLYIKQLKEFSGKKNDELRKAFIECAAVETFFAWHKYKEDKKNEEKKEETSYLVRLGFLGKQQSSPDEEAQKDLESGKIPDEFKRQMFYTFGDYRDIFFGKNMGIDMKTVEEKIKSIFPNSVKPDGQTRETWWNNNAKDIWNGMLCALSYDTKKRIKIEGIYAQLTQNNDYNKVTFDNGNTTLEIYATVPQFIRSFEEWAEEFCRKRKHKLAHIKDDCRSDTPGKMYCSGDGHDCTNEELKHNDMFADSYCPDCKKACRKYNKWIEKKVEEFYNQKSKYKKEHLKTSSNLDNKYVKEFYATSEGKYKSVDSFLDKLKERSHCHMDTLEGKIDFKNPLKTFSSSTYCKTCPLYGVQCRNTSDHCIQNSGNEKKWEHALDTIKIKNGAPTSINVQMIDRRGQYIQEHSENSFKESRLLKSVREQKWECSFVNKKMDVCKLKNFKENIDTDETITFKVLLENWLQDFIEGYYISKRKIDICTKKEEHTAIEGCKSKCECIGKWLKQKTTEWDEIKTHFNKQNRGDGYEIAHKVRNYFEKNAVQLKKWIDDLKHVKKIDDLRIVVLYDCANMDKETNKDMVSILLSQLKKEIKPFENQPHETTSPNYCDISPTHILTEPSQTDDTETLNPYDETPEDDTSTSSRPNFCPQVEPPPKPEVPQKPEETAEDTTEDTEEEAAAPPVAPSSGEEEAPKEVVPEKKPKEVPKPGPKAPKKRRPREVTHSILPEMVSISAFPLSVGIAFAALSYFVLKKKTKSTIDLLRVINIPKGDYGIPTMKSKNRYIPYASDRYKGKTYIYMEGDESDDYTYIGDISSSDITSSSESEYEEM
Organism_Source Plasmodium falciparum
Functional_Classification variant erythrocyte membrane protein
Cellular_Localization Plasma membrane
Gene_Names var1
UniProt_ID Q95W83
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HABP 6510
Peptide_Sequence GACAPYRRLHVCDQNLEQIE
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2315.61
Aliphatic_Index 83.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.75000
Charge_at_pH_7 -1.03192
Isoelectric_Point 5.54432
Hydrogen_Bond_Acceptors 33
Hydrogen_Bond_Donors 36
Topological_Polar_Surface_Area 1021.31000
X_logP_energy -10.50786
Interaction Information
Affinity KD=119 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural modifications to a high-activity binding peptide located within the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys
Release_Year 2007
PMID 17214546
DOI 10.1515/BC.2007.003