PPIRE19141

Target Protein Information
Protein_Name None
Protein_Sequence MAPQKAAAPDYSSAKDAKELLDMIGEEVYKEKVKNAANDFREKLKGTLSQATFEEAPKEQQTPGNPCELKYQWHTNATRGKNYPCRTGTEKRFSEVSGGECDEKKIKDNKGKEGACAPYRRLHLCVRNLENISALDKINNDTLLADVCLAALHEGAAISADHGQYQQTNDSSQLCTMLARSFADIGDIIRGKDLYRGNNGKDKLEENLKKIFGNIYKDVTKGGKNVDALKTRYEDATGNYYKLREDWWNANRQEIWKALTCDAPNGDVHYFRKTCSMGQSHVNDKCRCLNGDPPTYFDYVPQYLRWFEEWAEDFCTKRKHKLQNAIKICRGDSGNDRYCDLNGYDCTKTARGKNKRFSNDECYKCSLPCDHFVPWIDNQQKEFEKQKKKYAEEIKKAEEKKETSITIGDKTINNLYVQEFYQQLQSSYKDVEDFLQKLNEERICKKPPTVGKETADPVDFTKGKTEKTFSRTEYCRACPWCGIKRKADGTWERLDDMNKCVKEKKTYEKKNITDIPVLTPDKSQSRILDKYKNFCDDTNGKNSNGQKEKWECYYKKNEKDDVNGDSNICVLQNDKQNTEEENDRSYNSFFWKWVTEMLIDSIDWRKELKRCTNNKRGKCKNKKCNNDCKCFERWIEEKKNEWEKIVDYFKTQPGFDILSNNYDLALKTLLDVEDILTNIEDGYKEVKGSEHIRKMLENEKNQEEAAVAVTVKRNTIDLLIEHELDEADLCLDTHLEDEDCSDEDDDHEEEVYVNNPCAKPSGSYPSLANEAAHQMHKAAKTQLSGRGGRRTLKADASKGEYKRGGQGNTLNGDICKITKNYTNDIRSNGGACKGKDGSNERFKIGTEWSNVEDKKTTSYSDVYLPPRREHMCTSNLENLDVGSVTENGKAIHSLLGDVILTAKMDAAEIINRYKSQNSIGDPIDKKHQESICRAIRYSFADIGDIIRGRDIWDNETGMNHLKGHLEKVFKNIKEKLPGIQDKYTGDEKNNPPYKLLREDWWEANRHQVWRAMKCATKKDKNMKCNGIPIEDYIPQRLRWMTEWSEWFCKMQSVEYEKLKEKCDNCKNKDGGKDCTNVDSVCKPCAKQCKEYKEKIKNWEEQWRKISDKYNLLYLQAETTARNAGATSFDGTDPDYKQVVDFFKELQKTIKSSASKRPKRSTDGTTTDPTLTSPYFTAAGYIHQELPNMGCISQTHFCGDNNKKEYAFRDKPTDHDKVCDCESGEKLQYKKKEGIVLEEPCNVVKTLLKDKNENSDIGECIRKYKDGNEKYPVWDCTRNKIKIGEEGAYMPPRRQKLCVDFLKQLKDQTDEKLRDAFIKSAAAETFLSWHKYKEDKKKENPTEEAPSLDVEAQTQLNDGIIPEEFKRQMFYTFGDYRDLCLGKDIGNDVPIVNNNITTAFQNGAQNPSDQDTDSQRQVFWGTYGKDIWEGMLCALEKITEKQMTFTDKHEYTFDKVTFSGDKSPILEKFAQTPQFLRWMTEWGEHFCRERKEKVEILRTECAGCEVSDNDGSCHKNGEECQKCREECKKYQKWLEKWRENYDKQKVKFKTDKEGYNDDPDTIQSTEAYEYLGKKLKNITFTSGTTNGDCKCMQEKSKQESHDGSITDNMPESLDKEPQEVRGKCTCDSPTKKPEVLPVSPTSQDEACKIVDAILDPNSGTGYNDACEEKYGNGKTAYPGWKCTTNKIEKGKEDDVVCIPPRRQKLYIKQLKEFSGKKNDELRKAFIECAAVETFFAWHKYKEDKKNEEKKEETSYLVRLGFLGKQQSSPDEEAQKDLESGKIPDEFKRQMFYTFGDYRDIFFGKNMGIDMKTVEEKIKSIFPNSVKPDGQTRETWWNNNAKDIWNGMLCALSYDTKKRIKIEGIYAQLTQNNDYNKVTFDNGNTTLEIYATVPQFIRSFEEWAEEFCRKRKHKLAHIKDDCRSDTPGKMYCSGDGHDCTNEELKHNDMFADSYCPDCKKACRKYNKWIEKKVEEFYNQKSKYKKEHLKTSSNLDNKYVKEFYATSEGKYKSVDSFLDKLKERSHCHMDTLEGKIDFKNPLKTFSSSTYCKTCPLYGVQCRNTSDHCIQNSGNEKKWEHALDTIKIKNGAPTSINVQMIDRRGQYIQEHSENSFKESRLLKSVREQKWECSFVNKKMDVCKLKNFKENIDTDETITFKVLLENWLQDFIEGYYISKRKIDICTKKEEHTAIEGCKSKCECIGKWLKQKTTEWDEIKTHFNKQNRGDGYEIAHKVRNYFEKNAVQLKKWIDDLKHVKKIDDLRIVVLYDCANMDKETNKDMVSILLSQLKKEIKPFENQPHETTSPNYCDISPTHILTEPSQTDDTETLNPYDETPEDDTSTSSRPNFCPQVEPPPKPEVPQKPEETAEDTTEDTEEEAAAPPVAPSSGEEEAPKEVVPEKKPKEVPKPGPKAPKKRRPREVTHSILPEMVSISAFPLSVGIAFAALSYFVLKKKTKSTIDLLRVINIPKGDYGIPTMKSKNRYIPYASDRYKGKTYIYMEGDESDDYTYIGDISSSDITSSSESEYEEM
Organism_Source Plasmodium falciparum
Functional_Classification variant erythrocyte membrane protein
Cellular_Localization Plasma membrane
Gene_Names var1
UniProt_ID Q95W83
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HABP 6515
Peptide_Sequence GERTKGYCRCNDDQVPTYED
Peptide_Length 20
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)CN)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2349.49
Aliphatic_Index 14.50000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.80000
Charge_at_pH_7 -2.12308
Isoelectric_Point 4.22907
Hydrogen_Bond_Acceptors 37
Hydrogen_Bond_Donors 40
Topological_Polar_Surface_Area 1110.85000
X_logP_energy -14.49756
Interaction Information
Affinity KD=182 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural modifications to a high-activity binding peptide located within the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys
Release_Year 2007
PMID 17214546
DOI 10.1515/BC.2007.003