PPIRE19143

Target Protein Information
Protein_Name None
Protein_Sequence MAPQKAAAPDYSSAKDAKELLDMIGEEVYKEKVKNAANDFREKLKGTLSQATFEEAPKEQQTPGNPCELKYQWHTNATRGKNYPCRTGTEKRFSEVSGGECDEKKIKDNKGKEGACAPYRRLHLCVRNLENISALDKINNDTLLADVCLAALHEGAAISADHGQYQQTNDSSQLCTMLARSFADIGDIIRGKDLYRGNNGKDKLEENLKKIFGNIYKDVTKGGKNVDALKTRYEDATGNYYKLREDWWNANRQEIWKALTCDAPNGDVHYFRKTCSMGQSHVNDKCRCLNGDPPTYFDYVPQYLRWFEEWAEDFCTKRKHKLQNAIKICRGDSGNDRYCDLNGYDCTKTARGKNKRFSNDECYKCSLPCDHFVPWIDNQQKEFEKQKKKYAEEIKKAEEKKETSITIGDKTINNLYVQEFYQQLQSSYKDVEDFLQKLNEERICKKPPTVGKETADPVDFTKGKTEKTFSRTEYCRACPWCGIKRKADGTWERLDDMNKCVKEKKTYEKKNITDIPVLTPDKSQSRILDKYKNFCDDTNGKNSNGQKEKWECYYKKNEKDDVNGDSNICVLQNDKQNTEEENDRSYNSFFWKWVTEMLIDSIDWRKELKRCTNNKRGKCKNKKCNNDCKCFERWIEEKKNEWEKIVDYFKTQPGFDILSNNYDLALKTLLDVEDILTNIEDGYKEVKGSEHIRKMLENEKNQEEAAVAVTVKRNTIDLLIEHELDEADLCLDTHLEDEDCSDEDDDHEEEVYVNNPCAKPSGSYPSLANEAAHQMHKAAKTQLSGRGGRRTLKADASKGEYKRGGQGNTLNGDICKITKNYTNDIRSNGGACKGKDGSNERFKIGTEWSNVEDKKTTSYSDVYLPPRREHMCTSNLENLDVGSVTENGKAIHSLLGDVILTAKMDAAEIINRYKSQNSIGDPIDKKHQESICRAIRYSFADIGDIIRGRDIWDNETGMNHLKGHLEKVFKNIKEKLPGIQDKYTGDEKNNPPYKLLREDWWEANRHQVWRAMKCATKKDKNMKCNGIPIEDYIPQRLRWMTEWSEWFCKMQSVEYEKLKEKCDNCKNKDGGKDCTNVDSVCKPCAKQCKEYKEKIKNWEEQWRKISDKYNLLYLQAETTARNAGATSFDGTDPDYKQVVDFFKELQKTIKSSASKRPKRSTDGTTTDPTLTSPYFTAAGYIHQELPNMGCISQTHFCGDNNKKEYAFRDKPTDHDKVCDCESGEKLQYKKKEGIVLEEPCNVVKTLLKDKNENSDIGECIRKYKDGNEKYPVWDCTRNKIKIGEEGAYMPPRRQKLCVDFLKQLKDQTDEKLRDAFIKSAAAETFLSWHKYKEDKKKENPTEEAPSLDVEAQTQLNDGIIPEEFKRQMFYTFGDYRDLCLGKDIGNDVPIVNNNITTAFQNGAQNPSDQDTDSQRQVFWGTYGKDIWEGMLCALEKITEKQMTFTDKHEYTFDKVTFSGDKSPILEKFAQTPQFLRWMTEWGEHFCRERKEKVEILRTECAGCEVSDNDGSCHKNGEECQKCREECKKYQKWLEKWRENYDKQKVKFKTDKEGYNDDPDTIQSTEAYEYLGKKLKNITFTSGTTNGDCKCMQEKSKQESHDGSITDNMPESLDKEPQEVRGKCTCDSPTKKPEVLPVSPTSQDEACKIVDAILDPNSGTGYNDACEEKYGNGKTAYPGWKCTTNKIEKGKEDDVVCIPPRRQKLYIKQLKEFSGKKNDELRKAFIECAAVETFFAWHKYKEDKKNEEKKEETSYLVRLGFLGKQQSSPDEEAQKDLESGKIPDEFKRQMFYTFGDYRDIFFGKNMGIDMKTVEEKIKSIFPNSVKPDGQTRETWWNNNAKDIWNGMLCALSYDTKKRIKIEGIYAQLTQNNDYNKVTFDNGNTTLEIYATVPQFIRSFEEWAEEFCRKRKHKLAHIKDDCRSDTPGKMYCSGDGHDCTNEELKHNDMFADSYCPDCKKACRKYNKWIEKKVEEFYNQKSKYKKEHLKTSSNLDNKYVKEFYATSEGKYKSVDSFLDKLKERSHCHMDTLEGKIDFKNPLKTFSSSTYCKTCPLYGVQCRNTSDHCIQNSGNEKKWEHALDTIKIKNGAPTSINVQMIDRRGQYIQEHSENSFKESRLLKSVREQKWECSFVNKKMDVCKLKNFKENIDTDETITFKVLLENWLQDFIEGYYISKRKIDICTKKEEHTAIEGCKSKCECIGKWLKQKTTEWDEIKTHFNKQNRGDGYEIAHKVRNYFEKNAVQLKKWIDDLKHVKKIDDLRIVVLYDCANMDKETNKDMVSILLSQLKKEIKPFENQPHETTSPNYCDISPTHILTEPSQTDDTETLNPYDETPEDDTSTSSRPNFCPQVEPPPKPEVPQKPEETAEDTTEDTEEEAAAPPVAPSSGEEEAPKEVVPEKKPKEVPKPGPKAPKKRRPREVTHSILPEMVSISAFPLSVGIAFAALSYFVLKKKTKSTIDLLRVINIPKGDYGIPTMKSKNRYIPYASDRYKGKTYIYMEGDESDDYTYIGDISSSDITSSSESEYEEM
Organism_Source Plasmodium falciparum
Functional_Classification variant erythrocyte membrane protein
Cellular_Localization Plasma membrane
Gene_Names var1
UniProt_ID Q95W83
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HABP 6520
Peptide_Sequence YNKKIKDVKRNCRGKDDEDK
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2452.77
Aliphatic_Index 34.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 4.60000
Charge_at_pH_7 2.93694
Isoelectric_Point 9.91090
Hydrogen_Bond_Acceptors 38
Hydrogen_Bond_Donors 42
Topological_Polar_Surface_Area 1189.05000
X_logP_energy -13.36396
Interaction Information
Affinity KD=132 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural modifications to a high-activity binding peptide located within the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys
Release_Year 2007
PMID 17214546
DOI 10.1515/BC.2007.003