PPIRE19146

Target Protein Information
Protein_Name BTB/POZ domain-containing protein KCTD11
Protein_Sequence MLGAMFRAGTPMPPNLNSQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLLDALRELEASQGTPAPTAALLHADVDVSPRLVHFSARRGPHHYELSSVQVDTFRANLFCTDSECLGALRARFGVASGDRAEGSPHFHLEWAPRPVELPEVEYGRLGLQPLWTGGPGERREVVGTPSFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH
Organism_Source Homo sapiens
Functional_Classification substrate adaptor
Cellular_Localization Cytoplasm
Gene_Names KCTD11
UniProt_ID Q693B1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Cul349-68EN
Peptide_Sequence NSGLSFEXLYRXAYTMVLHK
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C
Chemical_Modification X8=(S)-2-(4--pentenyl)alanine; X12=(S)-2-(4--pentenyl)alanine
Cyclization_Method Side chain-side chain cyclization; X8<-->X12; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2243.57
Aliphatic_Index 78.00000
Aromaticity 0.15000
Average_Rotatable_Bonds 3.65000
Charge_at_pH_7 1.08867
Isoelectric_Point 9.14770
Hydrogen_Bond_Acceptors 32
Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 914.36000
X_logP_energy -8.32603
Interaction Information
Affinity KD=620 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Cullin3 - BTB Interface: A Novel Target for Stapled Peptides
Release_Year 2015
PMID 25848797
DOI 10.1371/journal.pone.0121149