PPIRE19171
Target Protein Information
| Protein_Name | Protein S100-A4 |
|---|---|
| Protein_Sequence | MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK |
| Organism_Source | Homo sapiens |
| Functional_Classification | calcium binding proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | S100A4 |
| UniProt_ID | P26447 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | S100A4 C-terminal tail peptide |
|---|---|
| Peptide_Sequence | EFFEGFPDKQPRKK |
| Peptide_Length | 14 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1752.99 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.21429 |
| Average_Rotatable_Bonds | 4.14286 |
| Charge_at_pH_7 | 1.00109 |
| Isoelectric_Point | 9.43992 |
|---|---|
| Hydrogen_Bond_Acceptors | 23 |
| Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 718.99000 |
| X_logP_energy | -4.80733 |
Interaction Information
| Affinity | KD=1.05 mM |
|---|---|
| Affinity_Assay | NMR chemical shift perturbation |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structure of Ca2+-Bound S100A4 and Its Interaction with Peptides Derived from Nonmuscle Myosin-IIA |
| Release_Year | 2008 |
| PMID | 18410126 |
| DOI | 10.1021/bi702537s |