PPIRE19193

Target Protein Information
Protein_Name Protein Tat
Protein_Sequence MPGPWVAMIMLPQPKESFGGKPIGWLFWNTCKGPRRDCPHCCCPICSWHCQLCFLQKNLGINYGSGPRRRGTRGKGRRIRRTASGGDQRREADSQRSFTNMDQ
Organism_Source Bovine immunodeficiency virus (strain R29)
Functional_Classification Viral transcriptional activators
Cellular_Localization Nucleus
Gene_Names tat
UniProt_ID P19564
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BIVdimer
Peptide_Sequence SGPRPRGTRGKGRRIRRTASGRGTRGKGRRIRR
Peptide_Length 33
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3730.32
Aliphatic_Index 26.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 14.99735
Isoelectric_Point 13.58074
Hydrogen_Bond_Acceptors 54
Hydrogen_Bond_Donors 78
Topological_Polar_Surface_Area 1934.83000
X_logP_energy -30.10489
Interaction Information
Affinity KD=50 nM
Affinity_Assay gel shift assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure-based design of a dimeric RNA-peptide complex
Release_Year 2001
PMID 11226168
DOI 10.1093/emboj/20.1.178