PPIRE19195

Target Protein Information
Protein_Name Protein PA-X
Protein_Sequence MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFVSPKEAKKQLKKDLKSQGQCAGLPTKVSRRTSPALRILEPMWMDSNRTATLRASFLKCPKK
Organism_Source Influenza A virus (strain A/Northern Territory/60/1968 H3N2)
Functional_Classification RNA dependent RNA polymerases
Cellular_Localization Nucleus
Gene_Names PA
UniProt_ID P0DJT7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PB11-25A
Peptide_Sequence MDVNPTLLFLKVPAQNAISTTFPY
Peptide_Length 24
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2681.14
Aliphatic_Index 97.50000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.33333
Charge_at_pH_7 -0.00271
Isoelectric_Point 6.33059
Hydrogen_Bond_Acceptors 36
Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 999.99000
X_logP_energy -7.45500
Interaction Information
Affinity IC50=1.8 nM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Identification of a PA-Binding Peptide with Inhibitory Activity against Influenza A and B Virus Replication
Release_Year 2009
PMID 19841738
DOI 10.1371/journal.pone.0007517