PPIRE19200
Target Protein Information
| Protein_Name | Eukaryotic translation initiation factor 4E |
|---|---|
| Protein_Sequence | MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV |
| Organism_Source | Homo sapiens |
| Functional_Classification | Translation initiation factors |
| Cellular_Localization | Cytoplasm |
| Gene_Names | EIF4E |
| UniProt_ID | P06730 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Trp-Glu-Ala-Glu |
|---|---|
| Peptide_Sequence | WEAG |
| Peptide_Length | 4 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 461.47 |
|---|---|
| Aliphatic_Index | 25.00000 |
| Aromaticity | 0.25000 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -1.00024 |
| Isoelectric_Point | 3.84998 |
|---|---|
| Hydrogen_Bond_Acceptors | 6 |
| Hydrogen_Bond_Donors | 7 |
| Topological_Polar_Surface_Area | 203.71000 |
| X_logP_energy | -0.90720 |
Interaction Information
| Affinity | KD=7.41 mM |
|---|---|
| Affinity_Assay | NMR chemical shift perturbation |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Cooperative stacking and hydrogen bond pairing interactions of fragment peptide in cap binding protein with mRNA cap structure |
| Release_Year | 1991 |
| PMID | 1932073 |
| DOI | 10.1016/0304-4165(91)90249-g |