PPIRE19207

Target Protein Information
Protein_Name Histidine-rich protein PFHRP-II
Protein_Sequence MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
Organism_Source Plasmodium falciparum
Functional_Classification histidine rich proteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P05227
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HRP-2 peptide-I
Peptide_Sequence AHHAHHAADAHHAADAHHAAD
Peptide_Length 21
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2171.20
Aliphatic_Index 47.61905
Aromaticity 0.00000
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -2.27340
Isoelectric_Point 6.72006
Hydrogen_Bond_Acceptors 33
Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 986.66000
X_logP_energy -12.55620
Interaction Information
Affinity KD=0.73 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Development of diagnostic reagents: Raising antibodies against synthetic peptides of PfHRP-2 and LDH using microsphere delivery
Release_Year 2006
PMID 17113917
DOI 10.1016/j.imbio.2006.05.003