PPIRE19210

Target Protein Information
Protein_Name L-lactate dehydrogenase
Protein_Sequence MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA
Organism_Source Plasmodium falciparum (isolate CDC / Honduras)
Functional_Classification dehydrogenases
Cellular_Localization Cytoplasm
Gene_Names None
UniProt_ID Q27743
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LDH peptide-II
Peptide_Sequence NTALEIVNLHASPYVAPAAA
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2022.29
Aliphatic_Index 117.50000
Aromaticity 0.05000
Average_Rotatable_Bonds 2.90000
Charge_at_pH_7 -0.91018
Isoelectric_Point 5.36345
Hydrogen_Bond_Acceptors 28
Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 811.49000
X_logP_energy -7.90560
Interaction Information
Affinity KD=3.2 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Development of diagnostic reagents: Raising antibodies against synthetic peptides of PfHRP-2 and LDH using microsphere delivery
Release_Year 2006
PMID 17113917
DOI 10.1016/j.imbio.2006.05.003