PPIRE19211

Target Protein Information
Protein_Name L-lactate dehydrogenase
Protein_Sequence MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA
Organism_Source Plasmodium falciparum (isolate CDC / Honduras)
Functional_Classification dehydrogenases
Cellular_Localization Cytoplasm
Gene_Names None
UniProt_ID Q27743
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LDH peptide-III
Peptide_Sequence PKAKIVLVGSGMIGGVMATLIVQKNL
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCSC)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)[C@@H](C)CC)C(C)C)C(C)C)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C)[C@@H](C)CC)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2638.31
Aliphatic_Index 142.30769
Aromaticity 0.00000
Average_Rotatable_Bonds 3.53846
Charge_at_pH_7 2.99710
Isoelectric_Point 11.10307
Hydrogen_Bond_Acceptors 36
Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 981.53000
X_logP_energy -7.18380
Interaction Information
Affinity KD=5.3 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Development of diagnostic reagents: Raising antibodies against synthetic peptides of PfHRP-2 and LDH using microsphere delivery
Release_Year 2006
PMID 17113917
DOI 10.1016/j.imbio.2006.05.003