PPIRE19233

Target Protein Information
Protein_Name Protein E6
Protein_Sequence MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
Organism_Source Human papillomavirus type 16
Functional_Classification Viral regulatory proteins host cell cycle modulators
Cellular_Localization Nucleus
Gene_Names E6
UniProt_ID P03126
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name E6apc1
Peptide_Sequence KKFACPECPKRFMRSDHLSKHIKTHQNKK
Peptide_Length 29
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3524.19
Aliphatic_Index 30.34483
Aromaticity 0.06897
Average_Rotatable_Bonds 4.24138
Charge_at_pH_7 7.14691
Isoelectric_Point 10.91529
Hydrogen_Bond_Acceptors 52
Hydrogen_Bond_Donors 53
Topological_Polar_Surface_Area 1473.99000
X_logP_energy -14.63196
Interaction Information
Affinity IC50=1000 uM
Affinity_Assay in vitro association assay
PDB_ID 1RIK
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Design and Characterization of Helical Peptides that Inhibit the E6 Protein of Papillomavirus
Release_Year 2004
PMID 15182185
DOI 10.1021/bi049552a