PPIRE19235

Target Protein Information
Protein_Name Protein E6
Protein_Sequence MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
Organism_Source Human papillomavirus type 16
Functional_Classification Viral regulatory proteins host cell cycle modulators
Cellular_Localization Nucleus
Gene_Names E6
UniProt_ID P03126
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name E6apn1
Peptide_Sequence NLLQELLGQGGPSSGRPPPS
Peptide_Length 20
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2004.23
Aliphatic_Index 78.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.05000
Charge_at_pH_7 -0.00024
Isoelectric_Point 6.41015
Hydrogen_Bond_Acceptors 29
Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 870.22000
X_logP_energy -12.14433
Interaction Information
Affinity IC50=36.8 uM
Affinity_Assay in vitro association assay
PDB_ID 1RIJ
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Design and Characterization of Helical Peptides that Inhibit the E6 Protein of Papillomavirus
Release_Year 2004
PMID 15182185
DOI 10.1021/bi049552a