PPIRE19246

Target Protein Information
Protein_Name Urotensin-2 receptor
Protein_Sequence MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names UTS2R
UniProt_ID Q9UKP6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name hU-II
Peptide_Sequence ETPDcCFWKYCV
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C2<-->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1493.73
Aliphatic_Index 24.16667
Aromaticity 0.25000
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 -1.18686
Isoelectric_Point 4.18431
Hydrogen_Bond_Acceptors 21
Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 531.50000
X_logP_energy -2.55300
Interaction Information
Affinity Ki=0.79 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title New Insight into the Binding Mode of Peptide Ligands at Urotensin-II Receptor: Structure-Activity Relationships Study on P5U and Urantide
Release_Year 2009
PMID 19432421
DOI 10.1021/jm900148c