PPIRE19248

Target Protein Information
Protein_Name Urotensin-2 receptor
Protein_Sequence MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names UTS2R
UniProt_ID Q9UKP6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P5U
Peptide_Sequence DcXFWKYCV
Peptide_Length 9
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)CC(=O)O)C(=O)O
Chemical_Modification X2=penicillamine
Cyclization_Method Side chain-side chain cyclization; X2<-->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1120.31
Aliphatic_Index 32.22222
Aromaticity 0.33333
Average_Rotatable_Bonds 3.55556
Charge_at_pH_7 -0.12666
Isoelectric_Point 6.06225
Hydrogen_Bond_Acceptors 15
Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 395.46000
X_logP_energy -1.05760
Interaction Information
Affinity Ki=0.2 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title New Insight into the Binding Mode of Peptide Ligands at Urotensin-II Receptor: Structure-Activity Relationships Study on P5U and Urantide
Release_Year 2009
PMID 19432421
DOI 10.1021/jm900148c