PPIRE19268

Target Protein Information
Protein_Name Transcriptional coactivator YAP1
Protein_Sequence MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL
Organism_Source Homo sapiens
Functional_Classification Transcriptional co activators
Cellular_Localization Nucleus
Gene_Names YAP1
UniProt_ID P46937
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ac-PPPPYTV-NH2
Peptide_Sequence PPPPYTV
Peptide_Length 7
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 769.90
Aliphatic_Index 41.42857
Aromaticity 0.14286
Average_Rotatable_Bonds 2.00000
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Hydrogen_Bond_Acceptors 10
Hydrogen_Bond_Donors 7
Topological_Polar_Surface_Area 238.02000
X_logP_energy -0.76450
Interaction Information
Affinity KD=60 uM
Affinity_Assay fluorescence spectroscopy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Solution Structures of the YAP65 WW Domain and the Variant L30K in Complex with the Peptides GTPPPPYTVG N-(n-octyl)-GPPPY and PLPPY and the Application of Peptide Libraries Reveal a Minimal Binding Epitope
Release_Year 2001
PMID None
DOI 10.1006/jmbi.2001.5199