PPIRE19271

Target Protein Information
Protein_Name Transcriptional coactivator YAP1
Protein_Sequence MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL
Organism_Source Homo sapiens
Functional_Classification Transcriptional co activators
Cellular_Localization Nucleus
Gene_Names YAP1
UniProt_ID P46937
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ac-PPPPY
Peptide_Sequence PPPPY
Peptide_Length 5
Peptide_SMILES O=C(O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 569.66
Aliphatic_Index 0.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 1.60000
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Hydrogen_Bond_Acceptors 7
Hydrogen_Bond_Donors 4
Topological_Polar_Surface_Area 159.59000
X_logP_energy 0.22910
Interaction Information
Affinity KD=60 uM
Affinity_Assay fluorescence spectroscopy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Solution Structures of the YAP65 WW Domain and the Variant L30K in Complex with the Peptides GTPPPPYTVG N-(n-octyl)-GPPPY and PLPPY and the Application of Peptide Libraries Reveal a Minimal Binding Epitope
Release_Year 2001
PMID None
DOI 10.1006/jmbi.2001.5199