PPIRE19273

Target Protein Information
Protein_Name Transcriptional coactivator YAP1
Protein_Sequence MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL
Organism_Source Homo sapiens
Functional_Classification Transcriptional co activators
Cellular_Localization Nucleus
Gene_Names YAP1
UniProt_ID P46937
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ac-PLPPY
Peptide_Sequence PLPPY
Peptide_Length 5
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 585.70
Aliphatic_Index 78.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 2.20000
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Hydrogen_Bond_Acceptors 7
Hydrogen_Bond_Donors 5
Topological_Polar_Surface_Area 168.38000
X_logP_energy 0.76900
Interaction Information
Affinity KD=500 uM
Affinity_Assay fluorescence spectroscopy
PDB_ID 1K9R
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Solution Structures of the YAP65 WW Domain and the Variant L30K in Complex with the Peptides GTPPPPYTVG N-(n-octyl)-GPPPY and PLPPY and the Application of Peptide Libraries Reveal a Minimal Binding Epitope
Release_Year 2001
PMID None
DOI 10.1006/jmbi.2001.5199