PPIRE19278

Target Protein Information
Protein_Name Fibroblast growth factor receptor 4
Protein_Sequence MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
Organism_Source Homo sapiens
Functional_Classification tyrosine kinases
Cellular_Localization Plasma membrane
Gene_Names FGFR4
UniProt_ID P22455
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide 3
Peptide_Sequence WFVGLKKNGSSKRGPRT
Peptide_Length 17
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1918.23
Aliphatic_Index 40.00000
Aromaticity 0.11765
Average_Rotatable_Bonds 3.76471
Charge_at_pH_7 4.99709
Isoelectric_Point 12.54608
Hydrogen_Bond_Acceptors 27
Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 841.56000
X_logP_energy -9.62136
Interaction Information
Affinity EC50=10 uM
Affinity_Assay thymidine incorporation assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Introduction of a Chemical Constraint in a Short Peptide Derived from Human Acidic Fibroblast Growth Factor Elicits Mitogenic Structural Determinants
Release_Year 2003
PMID 12773037
DOI 10.1021/jm020543e