PPIRE19299

Target Protein Information
Protein_Name Neuropeptide FF receptor 2
Protein_Sequence MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names NPFFR2
UniProt_ID Q9Y5X5
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FFRFamide radioligand
Peptide_Sequence FFRF
Peptide_Length 4
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 615.73
Aliphatic_Index 0.00000
Aromaticity 0.75000
Average_Rotatable_Bonds 4.25000
Charge_at_pH_7 0.99798
Isoelectric_Point 10.55000
Hydrogen_Bond_Acceptors 6
Hydrogen_Bond_Donors 8
Topological_Polar_Surface_Area 212.52000
X_logP_energy 0.84407
Interaction Information
Affinity KD=0.2 nM
Affinity_Assay saturation binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Endogenous mammalian RF-amide peptides including PrRP kisspeptin and 26RFa modulate nociception and morphine analgesia via NPFF receptors
Release_Year 2013
PMID 23911743
DOI 10.1016/j.neuropharm.2013.07.012